Both had been rated doubtful for the last 16 tie, having picked up knocks during the weekend's 2-0 victory over Everton.
However, it now appears that the pair are available for selection after they were seen boarding the plane for the Spanish capital.
Veteran midfielder Paul Scholes was not part of the 22-man party, though. The 38-year-old has remained in Manchester to receive treatment on a knee injury.
Man United squad to face Real Madrid: De Gea, Lindegaard; Büttner, Evans, Evra, Ferdinand, Jones, Rafael, Smalling, Vidic; Anderson, Carrick, Cleverley, Giggs, Nani, Valencia, Young; Hernandez, Kagawa, Rooney, Van Persie, Welbeck