However, despite his side's dominance both domestically and in Europe over the last two seasons, Guardiola believes that United still have the quality within their ranks to cause an upset.
"Last season Bayern won everything and this season we are over 20 points ahead of our opponents with seven matches to spare," Guardiola told reporters.
"But I know in the deep of my heart which team we are going to play against. Maybe they haven't had a good season in the league but when I see [Wayne] Rooney, [Nemanja] Vidic, Rio [Ferdinand], Chicharito [Javier Hernandez] and [Danny] Welbeck, I see very good players.
"I don't know why United haven't played well in the league, but over one game or two games, they can beat us."