Manchester United have confirmed that a handful of his playing squad are suffering with a "virus".
Discussing the omission of his midfield trio, Ferguson admitted that he had little choice but to leave them out.
"Carrick is in bed with a virus," Ferguson told reporters. "Giggs has a bit of a virus and felt rough so he was sent home.
"Scholes is at home because he wasn't feeling great this morning. He played so well on Saturday and at 37, I can't expect him to play again three days later."
Antonio Valencia will also miss the match with an ankle problem.