The Argentine's inclusion from the off is one of four changes by Citizens manager Pep Guardiola from the derby win at Manchester United on Sunday.
Swans boss Paul Clement, meanwhile, has made one change from the side that beat West Bromwich Albion at the weekend.
Wayne Routledge misses out through injury so Jordan Ayew is drafted into the XI to replace him.
Federico Fernandez also returns to the bench after missing four games following the death of his father.
Swansea City: Fabianski; Naughton, van der Hoorn, Mawson, Olsson; Ki, Mesa, Carroll; Ayew; Dyer, Bony
Subs: Mulder, Fernandez, Rangel, Clucas, Fer, Narsingh, Abraham
Manchester City: Ederson; Danilo, Mangala, Otamendi, Delph; De Bruyne, Fernandinho, D. Silva; Sterling, Aguero, B. Silva
Subs: Bravo, Walker, Gundogan, Sane, Jesus, Zinchenko, Toure
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