New signing Siem de Jong will be absent, as will Cheick Tiote and Davide Santon, while long-term injury victims Papiss Cisse and Ryan Taylor are still a significant amount of time away from a return to action.
Manchester City manager Manuel Pellegrini faces similar selection issues as he prepares his team for the visit to St James' Park.
Eight players were missing as City slumped to a 3-0 defeat to Arsenal in the Community Shield, and while a number of the absentees will return, Alvaro Negredo, Eliaquim Mangala, and potentially Sergio Aguero, will miss out.
Newcastle United: LWDW
Manchester City: WDDL
Possible starting lineups
Newcastle United: Krul; Janmaat, Coloccini, Williamson, Haidara; Colback, Anita, Sissoko, Cabella; Riviere, Ferreyra
Manchester City: Hart; Clichy, Kompany, Nastasic, Kolarov; Fernando, Yaya Toure, Silva, Nasri; Jovetic, Dzeko
Sports Mole says: 1-2