Despite that setback to their bitter rivals, City stand 11 points clear at the top of the table ahead of the visit of Southampton.
Here, Sports Mole rounds up all of Man City's latest injury and suspension news ahead of the midweek clash.
Status: Minor doubt
Type of injury: Muscular
Possible return date: March 10 (vs. Southampton)
Nathan Ake has not featured for City since Boxing Day due to a muscular issue. However, Guardiola confirmed last week that the Netherlands international is back in training and may now be considered for squad selection on Wednesday.
MANCHESTER CITY'S SUSPENSION LIST
Man City have no players suspended for this game.