Despite upping his fitness regime over the past week, City will definitely be without key creative man De Bruyne this weekend, while fringe players Mangala and Bravo are also confirmed absentees.
There is a big question mark over the fitness of left-back Mendy, who started the season in impressive form before being struck down by an ankle injury that has seen him miss the Citizens' last two matches.
Fabian Delph remains on standby if the World Cup-winning defender misses out on inclusion, and Danilo's own fitness concerns means that Kyle Walker should stay in his traditional right-back role.
The other concern for Guardiola is in attack, as Sergio Aguero was not fit enough to play a full part in the midweek loss to Lyon, but he is expected to start against Cardiff in place of Gabriel Jesus.
Raheem Sterling and a reinvigorated Leroy Sane are the favourites to flank Aguero, who has scored 12 goals and set up two more in his last 12 outings against newly-promoted sides.