The Ivorian captains a City side showing six changes from their 3-2 win over Sunderland for their second cup meeting with the Championship side this term.
Frank Lampard, who scored twice in a 7-0 Capital One Cup victory in September, and Dedryck Boyata are among those given starts, while Willy Caballero remains in goal as Joe Hart and David Silva are rested.
Bacary Sagna, Aleksander Kolarov, James Milner and Fernando are recalled, with Pablo Zabaleta, Gael Clichy, Samir Nasri, Fernandinho and Martin Demichelis left out as Manuel Pellegrini rotates his squad.
Wednesday make four changes for their third-round visit to the Etihad Stadium. Experienced goalkeeper Chris Kirkland replaces Kieren Westwood, while Stevie May, Claude Dielna and Kieran Lee also come in.
Man City: Caballero; Sagna, Boyata, Mangala, Kolarov; Fernando, Toure; Milner, Navas, Lampard; Jovetic
Subs: Hart, Demichelis, Clichy, Nasri, Fernandinho, Celina, Silva
Sheff Wed: Kirkland; Semedo, Lees, Loovens, Dielna; Palmer, Lee, Maghoma, Helan; May, Nuhiu
Subs: Dawson, Maguire, Lavery, McCabe, Corry, Young, De Havilland