Gareth Barry and Carlos Tevez are out of the team that beat Fulham in the Premier League on Saturday, while Samir Nasri and Edin Dzeko, who scored the winner at Craven Cottage, come into the starting XI.
Dortmund have gone with an expected starting XI as Marco Reus and Robert Lewandowski lead the attack for the Germans.
Man City: Hart; Zabaleta, Kompany, Nastasic, Clichy; Garcia, Y Toure, Nasri, Silva; Aguero, Dzeko
Subs: Pantilimon, Lescott, Milner, Kolarov, Rodwell, Tevez, Balotelli
Borussia Dortmund: Weidenfeller; Schmelzer, Hummels, Subotic, Piszczek: Bender, Gundogan; Blaszczykowski, Gotze, Reus; Lewandowski
Subs: Langerak, F Santana, Kehl, Leitner, Grosskreutz, Perisic, Schieber