While they still have top spot to fight for, it appears likely that they will be unable to catch current leaders Bayern Munich.
With that in mind, City manager Manuel Pellegrini has been tipped to rotate his starting lineup in order to give some of his squad players some time on the pitch against Czech side Viktoria Plzen tomorrow night.
Pellegrini has already confirmed that England's number one goalkeeper Joe Hart will return to the team at the expense of Costel Pantilimon. The likes of James Milner, Micah Richards and Edin Dzeko are also said to be in contention.
City won the fixture between the two sides earlier in the group phase 3-0.
Man City: LWWWLW
Possible starting lineups
Man City: Hart; Kolarov, Lescott, Garcia, Richards; Fernandinho, Toure, Milner, Nasri; Negredo, Dzeko
Plzen: Kozacik; Hubnik, Prochazka, Cisovsky, Limbersky; Rajtoral, Petrzela, Kolar, Horvath; Horava, Tecl
Sports Mole says: 2-0