The Premier League champions are winless in their opening four group matches and thus need victories from their final two games to have any chance of qualification.
Mario Balotelli has not been included in City's last two matchday squads but could take a seat on the bench alongside Edin Dzeko, should Mancini choose to partner Sergio Aguero and Carlos Tevez in attack.
Cristiano Ronaldo scored a stoppage-time winner in the reverse fixture earlier this season and the Portuguese star will be aiming for more goals when he comes against the club apparently courting his services.
Man City: WWDDWL
Man City: Hart; Zabaleta, Kompany, Nastasic, Kolarov; Barry, Garcia, Toure; Silva, Aguero, Tevez
Madrid: Casillas; Arbeloa, Pepe, Ramos, Coentrao; Alonso, Khedira; Di Maria, Ozil, Ronaldo; Benzema
Sports Mole says: 2-2