Lorient responded positively through Raphael Guerreiro, who had an effort saved from an acute angle, but Njie was proving to be a major threat for Lyon and he forced a solid save out of Benjamin Lecomte from just inside the penalty area.
Lyon doubled their advantage with six minutes left before the interval. Nabil Fekir was given the ball on the right-hand side of the penalty area before drilling the ball across goal and into the far corner.
Lorient were offering very little as Lyon threatened more goals and a fourth soon arrived with just over 20 minutes remaining when Fekir found the corner from 12 yards.
Lyon maintained their push in the latter stages but after failing to register a fifth of the night, they were happy to settle for their biggest win of the season.