St Etienne, meanwhile, have astonishingly lost five matches in a row, so Claude Puel will be desperate to stop the rot at the Groupama Stadium.
It has been a mixed start for Rudi Garcia's side, who showed their capabilities in August by knocking out Juventus and Manchester City to reach the semi-final of the Champions League.
After being seventh prior to the curtailment of all French football last season due to the coronavirus pandemic, though, Lyon have no European football to contend with this season so are looking to use that to their advantage to get back into a Champions League qualification position.
It has not quite turned out that way yet, with too many draws halting their progression up the table. Discipline has been an issue, with Marcelo sent off in last weekend's 1-1 draw at Lille and Melvin Bard also given his marching orders in the previous match against Monaco.
However, Garcia's side are unbeaten since matchday three, showing their resolve in earning the draw at Lille despite having a man disadvantage for the majority of the second half. The 56-year-old will be looking to turn those draws into wins, starting with Sunday against a St Etienne side who know little different to defeat at present.
Indeed, not for the first time in his managerial career, Puel is under intense pressure after leading his side to five consecutive defeats.
It is a good job his side earned 10 points from their first four matches; hypothetically, if you turned just one of those early wins into a draw instead, St Etienne would currently lie in the relegation zone.
Les Verts were dismal when losing 1-0 at home to Montpellier last week, failing to register a shot on target for the second match running having also failed to test Metz goalkeeper Alexandre Oukidja the previous weekend.
It is certainly not the best time for Puel and his men to be heading to a Lyon side packed with quality in attacking areas, then, with forwards Memphis Depay and Toko Ekambi scoring nine league goals between them already this season.
Lyon Ligue 1 form: DDDWWD
Saint-Etienne Ligue 1 form: DLLLLL
Garcia will be without defender Marcelo after his red card at Lille, but otherwise appears to be in the enviable position of a full squad to choose from.
Moussa Dembele only came off the bench in that draw and Garcia may be tempted to utilise a front three of him, Depay and Ekambi as he looks to turn draws into wins.
With his side looking so insipid offensively of late, the 59-year-old may be tempted to shake things up in attacking areas.
Lyon possible starting lineup:
Lopes; Dubois, Denayer, Diomande, Cornet; Paqueta, Mendes, Aouar; Ekambi, Dembele, Depay
Saint-Etienne possible starting lineup:
Moulin; Moueffek, Sow, Kolodziejczak, Silva; Youssouf, Neyou, Camara; Benkhedim, Hamouma, Khazri
We say: Lyon 3-0 Saint-Etienne
With St Etienne failing to test the opposition goalkeeper in their last two matches against worse opposition than Lyon, we cannot see anything beyond a comfortable home win.
Depay and Dembele should have too much in tandem for a side bereft of confidence to handle.