The Reds make the trip to South Wales having comfortably sealed their place in the semi-finals of the Champions League, and a league and European double remains a realistic goal for Jurgen Klopp's side.
However, they know that even a perfect end to the season may not be enough to pip Manchester City to the title, and they could be knocked off top spot by the time they face Cardiff on Sunday.
Here, Sports Mole looks at how the Merseysiders could line up for another must-win match.
Klopp was confident enough to rest Roberto Firmino from the start in midweek and, while the Brazilian still played the entire second half, he will return to the XI this weekend with fresher legs.
Mohamed Salah and Sadio Mane are expected to continue alongside him in the front three, while behind them the in-form captain Jordan Henderson will be pushing for a recall having impressed when given more licence to get forward in recent weeks.
At the back, Klopp could see the match as a good opportunity to give Joe Gomez some much-needed minutes following his recent return from injury, but Friday's home game against already-relegated Huddersfield Town may be an even kinder way to ease him back into first-team action.
Dejan Lovren will be assessed after missing the Porto game with illness, while Adam Lallana is expected to be in contention and Alex Oxlade-Chamberlain is entering the final stages of his year-long recovery from a knee injury.