The Uruguayan has served a one-match ban for improper conduct and could be joined in the starting lineup by the fit-again Steven Gerrard.
Mario Balotelli, left out of the Sunderland match, is also expected to feature at the Etihad Stadium.
League leaders City are so far unbeaten at home this season.
Man City: WLWWDL
Man City: Hart; Richards, Lescott, Kompany, Clichy; Yaya, Barry, Silva, Nasri; Balotelli, Aguero.
Liverpool: Reina; Johnson, Agger, Skrtel, Enrique; Downing, Gerrard, Adam, Spearing, Kuyt; Suarez.
Sports Mole says: 2-1