After finishing ninth in the league table last season, the expectation on the Foxes is to push for a European place.
The striker is serving a ban after being sent off in the Foxes' 2-0 victory over Wolverhampton Wanderers on August 18.
In a game of this magnitude on Saturday, it is far from ideal for Leicester to lose the attacker, but Puel can draw on the fact that his team are on a decent run of form.
The Foxes were unfortunate to lose 2-1 to Manchester United on the opening weekend, and they have since responded with wins over Wolves and Southampton.
Puel's side will head into this weekend's contest as underdogs due to Liverpool's positive form, but they have home comforts on their side.
In truth, the club can afford to have an off day given that they have winnable fixtures against Bournemouth, Huddersfield and Newcastle United coming up.
Recent form: LWW
Recent form (all competitions): LWWW
With the Reds sat at the top of the table, talk of them winning the league title is not going to slow down.
However, it is worth noting that the Merseyside outfit share the same number of points as Tottenham Hotspur, Chelsea and Watford, who currently occupy fourth spot.
It has been a perfect start to the season in terms of results for Liverpool as they have beaten West Ham United, Crystal Palace and Brighton & Hove Albion without conceding a goal.
To win titles, sometimes players have to grind out wins and still get over the line when playing below par, and at the moment, that is what the Reds seem to be doing.
Playing away from Anfield is statistically worse for Liverpool and they were given a hard test at Selhurst Park when they faced Crystal Palace, but they managed to come away with a 2-0 triumph.
On paper, Saturday's fixture is a game that Liverpool should win, but they have struggled in these sort of games in the past, and there is extra pressure on them due to the expectation this season.
Usually, the club drift along the sidelines with the main focus on the likes of Manchester City and Manchester United in the title race, but Klopp's men are front and centre at the moment, and it is all about whether they can handle the pressure.
Recent form: WWW
For the home side, they already know that Vardy will be unavailable as he serves the second of a three-match ban, but that does open the door to other talent.
Kelechi Iheanacho was given the starting role against Southampton and he could keep his place in a bid to become the first player to score against the Reds this season.
Caglar Soyuncu is yet to be seen in a competitive fixture by Leicester fans, but the defender may still have to wait for his debut as he tries to get up to speed on the training pitch.
The skipper made another cameo appearance against Brighton last weekend, and he impressed with his energy and skill on the ball, which must give Klopp something to think about ahead of team selection.
On the other hand, why change a winning formula?
Leicester City possible starting lineup:
Schmeichel; Chilwell, Maguire, Morgan, Amartey; Ndidi, Mendy; Gray, Maddison, Pereira; Iheanacho
Liverpool possible starting lineup:
Alisson; Robertson, Gomez, Van Dijk, Alexander-Arnold; Keita, Wijnaldum, Milner; Salah, Firmino, Salah
Head To Head
Historically, Liverpool have come out on top when these two teams have met having won 47 of their 110 clashes, with 24 resulting in draws and Leicester claiming 39.
Recently, though, it has not been an easy contest for the Reds, despite the fact that they have won their last two meetings with the former Premier League champions.
In fact, in those games, Klopp's side conceded three goals, one of which ended in a dramatic 3-2 victory for Liverpool at the King Power Stadium.
In the last five matches between the two, the Merseyside outfit have failed to keep a clean sheet, with Leicester winning two of the fixtures in all competitions.
We say: Leicester City 1-2 Liverpool
There is no doubt that Liverpool will face a tough test at the King Power, and the fact that they have not yet hit top form suggests that Leicester will give them a major test. Puel may not have Vardy or Mahrez to cause damage to the Reds this time around, but back-to-back wins will give the team plenty of confidence heading into the showdown. However, it is only a matter of time before Liverpool get into full flow, and Klopp has the players that can get the job done.