Jurgen Klopp's side were well beaten by previous champions Manchester City on Thursday night in their first match since securing the title for the first time in 30 years, but they will be expected and eager to return to winning ways in this one.
The Reds still have a number of records to aim for this season, with five more wins needed from their final six games to record more points and wins than any other team in Premier League history.
Here, Sports Mole looks at how they could line up for Villa's visit.
Klopp has promised that he will not let Liverpool take their foot off the pedal in the closing weeks of the season, and that he will not hand out appearances "like sweets".
True to his word, the XI named against Manchester City was the same as the one he named against Crystal Palace in his previous match, and was what many would consider to be their strongest possible lineup.
However, one or two changes are expected to that team for this match - as much due to the quick turnaround in fixtures as the nature of their defeat against City.
James Milner is in contention against his former club having overcome a hamstring injury, while Dejan Lovren could also be available after missing out against City as a precaution.
Salah has scored 49 Premier League home goals in 59 outings for Liverpool and Chelsea and could join Alan Shearer as the only players to reach the half-century milestone in 60 games or fewer.
Roberto Firmino, meanwhile, will be looking to end a goal drought at home in the league which stretches back 16 months and 17 matches since March 2019.