The England international was the surprise omission from the Reds' XI for Saturday lunchtime's clash at Wembley Stadium, being replaced by Naby Keita in the only change from the 2-1 win against Leicester City.
Henderson has been restricted to just one start in the Premier League so far this season - that narrow win at the King Power Stadium a fortnight ago - after missing a chunk of pre-season action because of his World Cup exploits.
Klopp has suggested that the club captain could be recalled for the midweek Champions League tie with Paris Saint-Germain, however, with a run of five games before the end of the month.
"We need Hendo so much and I don't think it makes sense in the moment to play him day in, day out, that's the thing," he told Sky Sports News. "It is still a bit adapting to the intensity.
"Hendo needs his full physical strength. I'm sure he'll have that today when he comes on and on Tuesday as well."