The Citizens' 800-plus-day reign as England's top club may be over following defeat to Chelsea, but they are still on course to finish the season as treble winners.
City will also been keen to end the Premier League season on a high, starting with victory over newly-crowned champions Liverpool this week.
Here, Sports Mole rounds up City's latest injury and suspension news ahead of the contest.
Type of injury: Knee
Possible return date: Unknown
Sergio Aguero has undergone surgery on a knee injury he aggravated during the recent win over Burnley and is now set to miss a significant chunk of the remainder of the season.
Status: Minor doubt
Type of injury: Head
Possible return date: July 2 (vs. Liverpool)
Eric Garcia needed lengthy treatment after a collision with Ederson in Man City's first game back. The centre-back has served the recommended time to recover from concussion, but Guardiola may not want to throw him back in just yet.
MAN CITY'S SUSPENSION LIST
Return date: July 5 (vs. Southampton)
Fernandinho was sent off in the defeat to Chelsea and is serving the second match of his two-game ban.