An impressive 2-0 victory over Wolverhampton Wanderers at Molineux on Friday night ensured that they would be top on Christmas Day, but they were handed a further unexpected boost a day later when City fell to a shock home defeat at the hands of Crystal Palace.
Here, Sports Mole looks at how Liverpool could line up for the contest.
Changes could be in the offing for Liverpool with Arsenal and Manchester City next up either side of New Year's Day, although whether Klopp opts to rest the likes of Mohamed Salah, Roberto Firmino and Sadio Mane remains to be seen.
Salah has been playing as a central striker for much of the campaign and so is one of the more likely players to miss out due to the presence of Daniel Sturridge, despite scoring one and assisting another against Wolves last time out.
Other fringe players such as Adam Lallana, Xherdan Shaqiri and Nathaniel Clyne will be hopeful of starts too, although Trent Alexander-Arnold is nearing full fitness and could be in contention to return.
Naby Keita was in the wars against Wolves and, while he is back in training and expected to be available, Klopp could choose to rest him given his side's strength in depth in midfield.