Victory for the Reds could see them through to the last 16 should other results go their way, but defeat could also leave them needing to beat Napoli in the final matchday to progress.
Here, Sports Mole looks at how Jurgen Klopp could set his side up for the trip to Paris.
Doubts were raised over the fitness of Sadio Mane on Monday after he was taken ill, but the forward was back in training on Tuesday and is expected to be fit to start this match.
Joe Gomez has also overcome the problem which kept him out of the weekend win over Watford and should return at centre-back in place of Dejan Lovren, with Trent Alexander-Arnold's goalscoring display at Vicarage Road enough to keep his place.
Klopp is expected to revert back to the 4-3-3 formation for this difficult away trip, which should allow James Milner to return to the starting lineup.
Jordan Henderson's red card against Watford - and subsequent suspension for Sunday's Merseyside derby - increases the likelihood of him starting in Paris, although Naby Keita and Fabinho, the latter of whom has been linked with PSG, are pushing for starts too.