The Saints have enjoyed a considerable spike in form since that day, while Leicester continue to confound expectations under Brendan Rodgers.
That 9-0 thrashing of Southampton at St Mary's served as the moment when onlookers started to look at this Leicester team in a different light.
Beyond being a highly-organised, energetic group of players, the result enshrined in the minds of many that this was a side capable of beating anybody, of even challenging for the Premier League title.
A recent draw with Norwich City, along with defeats to Manchester City and Liverpool, killed talk of another shock title, but Leicester are nonetheless a team that firmly belong in the top four.
Under Rodgers, the Midlands side bring a ruthless blend of rapid transitional play and cutting edge in the final third, with the talismanic Jamie Vardy once again having a quietly world-class campaign, netting 17 goals in 19 league outings.
They are now a side that are expected to not just win but indeed thrill while doing so, and the meeting with Southampton is no exception.
In a way, it could be said that the 9-0 drubbing in front of their own fans, equalling the record for the biggest ever margin of victory in the Premier League, was the best possible thing to happen to Southampton this season.
That result left Southampton in the relegation zone, without a league win in five games, but it was also the catalyst for an impressive revival.
Since that drubbing, which naturally garnered worldwide attention, Southampton's performances have been tighter, more energetic, more purposeful all over the pitch.
They will need to be at their very best, and also have some luck, if they are to exorcise the demons of that gloomy October evening at the King Power on Saturday.
Leicester City Premier League form: WDLLWW
Leicester City form (all competitions): LLWWWD
Southampton Premier League form: LLWWDW
Southampton form (all competitions): LWWDWW
Southampton only have won sidelined player in the form of Yan Valery, who has been out due to a viral infection.
With a more or less full group of players to choose from, Hasenhuttl is likely to pick a similar side to the one that triumphed 1-0 over Tottenham Hotspur, including goalscorer Danny Ings in the number nine role.
Leicester City possible starting lineup:
Schmeichel; Soyuncu, Evans, Fuchs, Chilwell, Pereira; Maddison, Tielemans, Choudhury; Perez, Vardy
Southampton possible starting lineup:
McCarthy; Cedric, Stephens, Bednarek, Bertrand; Ward-Prowse, Hojbjerg, Romeu, Long; Redmond, Ings
We say: Leicester City 3-1 Southampton
Southampton will no doubt make a better game of this encounter compared with last October's mauling, but the home side have far too much quality and confidence in the final third at this moment in time, meaning that a comfortable Leicester victory serves as the most likely outcome.