Meanwhile, Brentford will play host to the Premier League high-flyers on Saturday afternoon sitting in fifth place in the Championship standings.
Ahead of Wednesday's top-flight meeting with West Ham United, Brendan Rodgers would have been aware that the pressure was growing on his side after their failure to defeat Aston Villa, Southampton and Burnley respectively.
However, the Foxes proved during the opening 45 minutes against the Hammers that they had rediscovered the confidence and swagger which have kept them in the top four of the Premier League table for much of this season.
With injuries being sustained to Jamie Vardy and Nampalys Mendy, the evening did not go perfectly for the Foxes, but a dominant 4-1 victory resulted in the club ending the night with a 14-point advantage over fifth-placed Manchester United.
Rodgers and his squad now have the welcome distraction of the FA Cup and EFL Cup, with the latter perhaps taking priority given that they are just one win away from a place in next month's final.
Nevertheless, despite the prospect of mass changes being made on Saturday lunchtime, Rodgers will want his fringe players to give him a reason to stop him entering the transfer market before the end of the month.
As far as Brentford are concerned, prolonging their interest in the FA Cup will divide opinion among their fanbase as they bid to remain in the Championship promotion hunt.
That said, this is an ideal opportunity for Thomas Frank's developing squad to test themselves against one of the best teams in the country in front of their own supporters.
While Frank will be expected to field a starting lineup which is stronger than the one from the narrow win over Stoke City in round three, the club's priorities are elsewhere with a huge showdown with Nottingham Forest coming up on Tuesday night.
With the pressure off, that could play into the London outfit's favour, and whomever takes to the pitch at the weekend in front of the television cameras will want to showcase why Brentford are genuine contenders to earn a spot in next season's Premier League.
Brentford FA Cup form form: W
Brentford form (all competitions): WLWWWD
Leicester City FA Cup competition form: W
Leicester City form (all competitions): WWDLLW
Despite Vardy missing out due to a glute injury, Kelechi Iheanacho may be left out of the side ahead of the meeting with Villa next week.
With Tuesday in mind, Frank will make alterations, with Emiliano Marcondes likely being given the chance to build on his winner against Stoke in the last round.
Brentford possible starting lineup:
Daniels; Racic, Jeanvier, Pinnock, Rasmussen; Marcondes, Yearwood, Norgaard; Marcondes, Castillo, Mbeumo
Leicester City possible starting lineup:
Ward; Justin, Morgan, Benkovic, Fuchs; Choudhury, Praet; Albrighton, Perez, Barnes; Gray
We say: Brentford 1-2 Leicester City
Despite the likelihood of changes being made, Leicester remain favourites here, and we expect the Foxes to grind out a hard-fought success against the Bees, who may make it difficult for the visitors during the opening hour of the contest.
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