The Slovenian's reign in charge of Leeds began with a scoreless defeat on Saturday as Brentford came out on top 2-0 at Griffin Park.
That loss ended a four-game unbeaten run that Leeds had achieved under caretaker boss Neil Redfearn, and Milanic will be desperate to get his first points on the board.
As for Reading, they go into the game on the back of an enthralling 3-3 draw against Wolverhampton Wanderers on Sunday.
Glenn Murray is sure to start after netting three goals in four games since his switch from Crystal Palace.
Reading have won their last four matches against Leeds, beating them 4-2 in the last meeting at Elland Road in March.
Possible starting lineups
Leeds: Silvestri; Byram, Bellusci, Pearce, Warnock; Bianchi, Cook, Austin, Mowatt; Antenucci, Doukara
Reading: Federici; Gunter, Obita, Hector, Pearce; Akpan, Norwood, Taylor, Blackman; Cox, Murray
Sports Mole says: 2-2