The Biancocelesti fell to a 3-0 loss on Saturday and are now seven points adrift of leaders Juventus, while Lecce are in the bottom three heading into this match.
It was just the Biancocelesti's second defeat in 25 league matches since September, although the other of those losses came four games ago against Atalanta BC.
Two defeats in their four matches since last month's restart has effectively killed off Lazio's Scudetto aspirations, with Juve now on the brink of a ninth-straight triumph.
Simone Inzaghi will at the very least want to put some pressure on the league leaders, though, which his side can achieve by overcoming a struggling Lecce side on Tuesday.
The Giallorossi fell to a 4-2 reverse at the hands of Sassuolo on Saturday and are one point from safety, though 17th-placed Genoa have a game in hand to play on Sunday.
That was Lecce's fourth successive loss since resuming their Serie A campaign, while going further back it is six defeats on the spin.
That will surely be of concern for Liverani ahead of this midweek clash given that only Atalanta have scored more than Lazio's 66 goals this season.
With Immobile and Caicedo back in their ranks, this appears to be the perfect opportunity for Inzaghi's men to flex their muscles and show that the title race is not over just yet.
Lazio have won three of their last four meetings with Lecce, drawing the other in a run that includes a 4-2 victory when the sides last met eight months ago.
Lecce's Serie A form: LLLLLL
Lazio's Serie A form: WWLWWL
Immobile and Caicedo, who have 37 Serie A goals between them this season, will return from suspension for the trip to Stadio Via del Mare.
Lucas Leiva gave Lazio some added midfield balance before Milan ran away with the game, and he may well retain his place in the side on Tuesday.
Lecce possible starting lineup:
Gabriel; Rispoli, Donati, Lucioni, Paz, Calderoni; Mancosu, Tachtsidis, Barak; Babacar, Farias
Lazio possible starting lineup:
Strakosha; Patric, Acerbi, Radu; Lazzari, Milinkovic-Savic, Parolo, Lucas, Jony; Caicedo, Immobile
We say: Lecce 0-3 Lazio
Lazio can close the gap on Juventus to four points ahead of the leaders' trip to Milan a little later on Tuesday. The visitors may have been a little off colour at the weekend, but we are expecting them to show exactly what they are all about when back to full strength against out-of-form Lecce.