Lazio make four changes to the side that suffered a shock 1-0 loss to Ludogorets Razgrad in the Europa League on Thursday, with Antonio Candreva, Stefano Mauri, Cristian Ledesma and Alvaro Gonzalez all coming into the team against Sassuolo tonight.
Miroslav Klose starts up front for the hosts, having not scored since a 1-0 win over Inter Milan at the beginning of January.
The visitors have lost their last five league games and are currently bottom of Serie A.
Lazio: Berisha; Konko, Biava, Dias, Radu; Ledesma, Gonzalez; Candreva, Mauri, Lulic; Klose
Subs: Marchetti, Strakosha, Novaretti, Cavanda, Cana, Ciani, Biglia, Onazi, Keita, Kakuta, Anderson, Perea
Sassuolo: Pegolo; Mendes, Cannavaro, Ariaudo; Rosi, Chibsah, Magnanelli, Biondini, Longhi; Floccari, Zaza
Subs: Pomini, Antei, Pucino, Bianco, Gazzola, Ziegler, Marrone, Missiroli, Farias, Floro Flores, Sansone, Berardi
Keep up with the game with Sports Mole's live commentary here.