Bologna vs. Sampdoria (Sunday, 11.30am)
Meanwhile, Sampdoria are looking to claim their first away victory at the Stadio Renato Dall'Ara since November 2003.
We say: Bologna 1-1 Sampdoria
Both sides will be keen to address their current form and get back to winning ways as they head into the final third of this campaign. However, with little to separate the two mid-table sides, a score draw could be on the cards at the Stadio Renato Dall'Ara.
Torino vs. Inter Milan (Sunday, 2.00pm)
Nearing the final stretch in their pursuit of a first Scudetto in over a decade, Inter Milan travel to meet Torino on Sunday afternoon, with the hosts still under the shadow of a debilitating COVID-19 outbreak.
The Granata had their two previous games postponed at short notice before returning with a defeat against lowly Crotone last week, while Inter saw off potential challengers Atalanta at San Siro.
We say: Torino 0-2 Inter Milan
For Torino, there could be no worse team to face at a time when troubled by questions of form and fitness than this predatory Inter outfit.
Though both sides set up in a similar 3-5-2 formation, the visitors' far greater individual quality and match-sharpness should ensure a straightforward day at the office for the Scudetto favourites, who march on towards their 19th title.
Parma vs. Roma (Sunday, 2.00pm)
With the visitors putting together three straight wins in all competitions, they travel north fully expecting to add another maximum points haul to their already impressive total.
We say: Parma 1-2 Roma
The prospects of finally earning a desperately-needed first win of the year are apparently slim for Parma this Sunday, as Roma are clicking back into gear and have effectively sewn-up progress in Europe - thereby avoiding distraction ahead of their second leg with Shakhtar next week.
With the recently returned-to-the-fold pair of Stephan El Shaarawy and Edin Dzeko potentially both playing a prominent role, Parma's brittle back four have little hope of holding out for 90 minutes against one of Serie A's most deadly offensive units.
Cagliari vs. Juventus (Sunday, 5.00pm)
In a week when they crashed out of the Champions League, under-performing Juventus must immediately bounce back at relegation battlers Cagliari on Sunday, if they wish to retain any faint hope of retaining the Scudetto this season.
It may not be a straightforward task either, as their Sardinian hosts have won two of their first three games with new manager Leonardo Semplici at the helm and are in need of points to keep their heads above water in the fight for Serie A survival.
We say: Cagliari 0-1 Juventus
Cagliari simply do not pose enough of an attacking threat to take advantage of the champions' current wobbles, with their woeful home form a factor too.
As Leonardo Semplici's unbeaten start inevitably comes to an end, a slither of pressure will be taken off the heavily-burdened shoulders of his younger counterpart, Andrea Pirlo, who simply must do all within his power to save both his side's season and his own job between now and May.
AC Milan vs. Napoli (Sunday, 7.45pm)
Former Milan stalwart Gennaro Gattuso, meanwhile, brings his inconsistent side to the second city after a midweek break, having crashed out of the Europa League in the previous round, and is intent on securing a top four place for his current club.
We say: AC Milan 2-1 Napoli
Milan have shown resilience to impress against Roma, Verona and Manchester United in recent games, despite key men being missing. Though their scintillating early-season form has subsided, the Rossoneri can still stay in contention for title glory with their first San Siro win in over a month.
Meanwhile, Napoli's less-than-impressive away record is poised to continue this weekend, as they seemingly lurch from triumph to disaster and back again on a fortnightly basis.