Bologna come into the clash with the reigning champions off the back of an ill-tempered 2-2 home draw with Lazio which extends their winless run to four games.
Juventus' win over Inter last time out was a significant result for the defending champions as they chase yet another Serie A crown.
It moved the Bianconeri to the summit of the league standings and saw Inter lose their first domestic contest of the season, leaving Juventus as the only remaining unbeaten side the division.
Goals from Paulo Dybala and substitute Gonzalo Higuain either side of a Lautaro Martinez penalty proved enough to settle the contest, and gives Maurizio Sarri the welcome headache of choosing which Argentine forward to pair with Cristiano Ronaldo.
Juventus have been their usual irresistible selves this season, with a pair of back-to-back draws against Fiorentina in Serie A and Atletico Madrid in the Champions League the only blip on an otherwise flawless campaign so far.
However, it appears that they have a real battle for the title on their hands again this year, with Antonio Conte's Inter capitalising on those two dropped points in Florence to go top of the league early on, and they now trail Juventus by just a point.
The Nerazzurri look set to provide Juventus with the sternest test of their title credentials since Sarri himself played the role of the plucky underdog with Napoli two seasons ago, narrowly missing out on the title.
Bologna are the next obstacle in the Bianconeri's path, and while they sit a respectable 11th in the table, only three points separate them from the relegation zone.
A decent start in which they went unbeaten in their first three games - winning two - has tailed off, with Bologna failing to register a victory in their next four.
Juventus form: DWWWWW
Bologna form: WWLDLD
Sarri is dealing with a minor injury crisis at the back, with neither of his senior right-backs fit and available at present.
As a result, Juan Cuadrado will likely continue to fill in there out of position. The rest of the defence is likely to be as expected, although veteran defender Giorgio Chiellini's long-term absence is a big blow for the side.
Former Napoli and Chelsea boss Sarri has plenty of options in midfield, but has settled on a preferred trio of Blaise Matuidi, Miralem Pjanic and Sami Khedira, meaning that new signings Aaron Ramsey and, in particular, Adrien Rabiot have been used somewhat sparingly.
However, the major question mark over the Bianconeri's next lineup is certainly who will get the nod between Dybala and Higuain to start next to Ronaldo in attack.
Juventus possible starting lineup:
Szczesny; Cuadrado, Bonucci, De Ligt, Sandro; Khedira, Pjanic, Matuidi; Bernardeschi; Higuain, Ronaldo
Bologna possible starting lineup:
Skorupski; Tomiyasu, Danilo, Bani, Krejci; Soriano, Poli; Orsolini, Svanberg, Sansone; Palacio
We say: Juventus 2-1 Bologna
Juventus have not made a habit of blowing teams away this season, with five of their six Serie A victories coming by a one-goal margin. Their quality makes them undoubted favourites to win, but the scoreline could be closer than expected once again.