Champions by 11 points last term, Juve are likely to hand a debut to Matthijs de Ligt, their most high-profile signing of the summer at a price of £67.5m.
The 19-year-old centre-back was key to Ajax's run to the Champions League semi-finals and will be expected to strengthen his new club's attempts to mirror their domestic dominance in European competition following their shock exit at the hands of the Dutch side in last season's quarter-finals.
De Ligt's fellow arrivals, such as Danilo, signed from Manchester City for £34.2m, could also figure, although they will be without coach Maurizio Sarri for his first match following his switch from Chelsea.
The club announced this week that the Europa League-winning coach has been suffering with pneumonia.
Here, Sports Mole rounds up their latest injury and suspension news.
Type of injury: Shoulder
Possible return date: Nov 24 (vs. Atalanta)
Number two goalkeeper Perin picked up a shoulder injury in training in April that meant he played no further part in the remainder of last season for Juve. As a result, third-choice stopper Carlo Pinsoglio should again be the substitute stopper this weekend.
Type of injury: Knee
Possible return date: Oct 6 (vs. Inter Milan)
Winger Pjaca suffered a serious left knee injury in a training session during his loan spell with Fiorentina, with scans revealing a ruptured ligament - the Croatia international's second long-term problem in as many years.
JUVENTUS' SUSPENSION LIST
Juventus have no players suspended for this match.
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