The hosts squandered a two-goal lead at Atletico Madrid on matchday one, while Leverkusen suffered a bitterly disappointing home defeat at the hands of Lokomotiv Moscow.
Always among the favourites for Champions League glory, Juventus' recent record in the competition is actually fairly poor with just one win in their last six European outings and three defeats in their last six at home.
Maurizio Sarri's side looked destined for a statement-making victory on matchday one when goals from Juan Cuadrado and Blaise Matuidi put them into a two-goal lead at the Wanda Metropolitano, only for Atletico to hit back with two goals in the final 20 minutes to rescue a draw.
One point from what is likely to be their most difficult assignment of the group stage is by no means a bad result, though, and the Italian champions will expect to chalk up their first victory on Tuesday night.
Juve have won all three of their matches since that Atletico draw, including a 2-0 triumph over SPAL on Saturday, and may even already have one eye on next weekend's top-of-the-table showdown with Inter Milan, who lead the way in Serie A with six wins from six.
The Champions League is no place to take your eye off the ball, though, even for a team still unbeaten across all competitions this season as Juventus are.
Having said that, Leverkusen would need to pull off a major shock if they are to come away with anything from the Juventus Stadium, particularly following their own matchday one setback.
The Bundesliga outfit were favourites going into their home match against Lokomotiv Moscow but slumped to a 2-1 defeat, following on from a 4-0 hammering at the hands of Borussia Dortmund four days earlier.
Champions League wins have been harder to come by - just two in their last 14 outings - although they did beat Juventus when they were paired together for the only previous time in 2001-02, a campaign which ended with Leverkusen reaching the final.
Juventus form: WDDWWW
Leverkusen form: WDLLWW
Juventus boast Champions League top scorer Cristiano Ronaldo in their ranks and the five-time winner of the competition is fit to play after returning from a minor thigh injury at the weekend.
Douglas Costa and Danilo, the latter of whom is one appearance short of 50 in European competition, have picked up similar issues so far this month and are also unlikely to feature as a result, forcing Sarri to again use Cuadrado as an emergency full-back.
Leverkusen will once again be without one of their key men in Leon Bailey, who has not played since suffering a muscle injury during the matchday one defeat to Lokomotiv.
There is better news regarding the fitness of Joel Pohjanpalo, though, with the Finnish attacker returning to the bench against Augsburg following 18 months out with persistent foot problems.
Juventus possible starting lineup:
Szczesny; Cuadrado, Bonucci, De Ligt, Silva; Khedira, Pjanic, Matuidi; Dybala; Ronaldo, Higuain
Leverkusen possible starting lineup:
Hradecky; Weiser, Dragovic, S Bender, Sinkgraven; Baumgartlinger, Aranguiz; Havertz, Amiri, Volland; Alario
We say: Juventus 2-0 Leverkusen
Leverkusen should put up a better fight than their matchday one result might suggest, but there is no getting away from the fact that Juventus will be firm favourites for this match. The Italian champions have superior quality throughout their team, not to mention the genius of Ronaldo up front should it prove to be stickier than the stats suggest.