The Azzurri boss praised Totti for his form this season and stated that he wants to take the 37-year-old to next summer's World Cup.
Speaking to Sport Mediaset, Prandelli said: "Before his injury, Totti did great things and proved he deserves a call-up. Then he stopped and is now getting ready for his comeback.
"We'll see how it goes, as I am keeping Totti under very close observation.
"I am great friends with Francesco. Before the injury he was playing at a stratospheric level and someone like him always makes the difference. Personally, I would take him to the World Cup."
Roma are currently second in Serie A.