O'Grady is partnered in attack by Vitesse Arnhem loanee Marcus Pedersen, who scored in their 1-1 draw with Sheffield Wednesday last time out, a result which helped Barnsley go two games unbeaten - their best run of the season.
Mick McCarthy, celebrating his one-year anniversary as Tractor Boys boss, names the same side for the seventh successive game, and includes two former Reds loanees, Ryan Tunnicliffe and Frank Nouble, in his squad.
Ipswich: Gerken; Chambers, Smith, Berra, Cresswell; Anderson, Hyam, Skuse, Tunnicliffe; Murphy, McGoldrick
Subs: Loach, Hewitt, Mings, Edwards, Tabb, Taylor, Nouble
Barnsley: Butland; Kennedy, Cranie, Wiseman, M'voto; O'Grady, Perkins, Fox, Mellis, McCourt; O'Grady, Pedersen
Subs: Hassell, O'Brien, Dibble, Scotland, Cywka, Etuhu, Jennings