Inter Milan vs. Sassuolo (Wednesday, 6.30pm)
In contrast, Sassuolo are searching for their first points since the restart as their return to action was marked by a dismal 4-1 defeat against a high-flying Atalanta side.
We say: Inter Milan 3-1 Sassuolo
Sassuolo have plenty of attacking players who are capable of causing problems for Inter, but Conte's side are expected to have too much quality for their opponents and we cannot see anything other than a comfortable home win.
Atalanta vs. Lazio (Wednesday, 8.45pm)
The match will be Lazio's first time back on the pitch for nearly four months following the coronavirus-enforced shutdown, and Simone Inzaghi's side trail leaders Juventus by one point as things stand.
We say: Atalanta 2-2 Lazio
The clash between Atalanta and Lazio promises to be a fascinating match-up between two of the country's most exciting sides this season. Both teams are packed with attacking talent and will be desperate to pick up all three points, but we are struggling to pick a winner for this one.
Roma vs. Sampdoria (Wednesday, 8.45pm)
Sampdoria will be looking to recover from their weekend defeat to Inter Milan when they travel to the Stadio Olimpico to take on Roma on Wednesday evening.
Roma, meanwhile, are returning to action for the first time since the coronavirus-enforced shutdown and are six points adrift of the Champions League places as things stand.
We say: Roma 2-0 Sampdoria
Sampdoria did not make life easy for Inter when the sides locked horns at the weekend, but Ranieri's men ultimately emerged empty-handed as the quality of I Nerazzurri shone through. A similar story is likely to occur on Wednesday, and we are backing Roma to mark their return to action with a comfortable three points.