The Nerazzurri have won just one of their last eight fixtures and have slipped 11 points behind third-placed Napoli, who occupy the final Champions League qualifying spot.
Their opponents Catania have lost their past three matches and sit bottom of the table, having picked up 13 points from their first 20 games.
They have lost all 10 of their fixtures away from home in the league this season and fell to a 3-0 defeat against Inter when the two sides met in September.
Inter Milan are still without long-term absentees Cristian Chivu and McDonald Mariga, while Fredy Guarin may not feature after his transfer to Juventus fell through earlier this week. Pablo Barrientos is suspended for Catania, but Francesco Lodi should return to the side after a ban.
Inter Milan: DLWLDL
Possible starting lineups
Inter Milan: Handanovic, Jonathan, Jesus, Rolando, Campagnaro, Nagatomo, Cambiasso, Zanetti, Alvarez, Palacio, Milito
Catania: Frison, Peruzzi, Spolli, Bellusci, Biraghi, Plasil, Lodi, Izco, Castro, Keko, Bergessio
Sports Mole says: 3-0