The Villans lie three points away from the relegation zone ahead of kickoff, with Steve Bruce's FA Cup finalists just two points better off.
The Hull fixture has been touted as Villa's best chance of adding to their points haul, as their final two matches of the season are visits to Manchester City and Tottenham Hotspur.
"We're not going to hide away from it," he told reporters. "There is a lot of pressure on the game. But we have got experienced players in there and hopefully everyone will rise to the occasion and get the result.
"It could be the biggest game of all our careers so far because of what is at stake. To keep a club the size of Aston Villa in the Premier League is a massive thing."
Villa currently occupy 16th place in the table, while Hull are in 13th.