Yannick Sagbo spearheads the attack, while Tom Huddlestone comes into midfield as the duo replace strikers Nikica Jelavic and Shane Long - both of whom are ineligible - from the 1-0 win over Swansea City last time out.
Harry Maguire, Bob Harris and Jose Baxter are the surviving members from the team which beat the Millers, while goalkeeper Mark Howard, Jamie Murphy and Conor Coady are among those handed starting berths.
Hull City Harper; Rosenior, Figueroa, Davies, Chester; Huddlestone, Meyler, Livermore, Boyd, Elmohamady; Sagbo
Sheffield United: Howard; Brayford, Harris, Maguire, Collins; Doyle, Coady, Scougall, Flynn; Baxter; Murphy
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