The hosts are currently bottom of Germany's top flight with just 17 points to show from their 26 matches this season, while Hoffenheim occupy ninth, just four points off the top six.
Paderborn finished second in the 2.Bundesliga last season to earn promotion to the top flight, but it would be fair to say that it has been a struggle for the team during the 2019-20 campaign.
Four wins, five draws and 17 defeats - that is how Paderborn have performed in Germany's top flight this term, leaving them bottom of the table with just 17 points from 26 matches.
Steffen Baumgart's side are six points behind 16th-placed Fortuna Dusseldorf, whom they shared the points with in a goalless draw last weekend, and 10 points off 15th-placed Mainz on the same number of matches.
It is difficult to imagine a scenario where the strugglers escape the relegation zone in the coming weeks, particularly considering that they have only picked up one league victory in 2020.
Hoffenheim, meanwhile, currently sit ninth in the table with 35 points to show from their 26 matches. They are four points off sixth-placed Wolfsburg as things stand but will need to improve in the coming weeks if they are to potentially claim a European spot for the 2020-21 season.
Alfred Schreuder's side suffered a 3-0 home defeat to Hertha Berlin on their return to action last weekend, while they conceded six unanswered goals to Bayern Munich just before the league was postponed.
Hoffenheim have not actually been victorious in the Bundesliga since the start of February, losing five of their last seven during an extremely disappointing run of form.
Die Kraichgauer ran out 3-0 winners in the reserve game with Paderborn earlier this season, though, and actually have the seventh-best away record in Germany's top flight during the 2019-20 campaign, picking up more points on their travels (19) than at home (16).
Paderborn Bundesliga form: DLLLLD
Hoffenheim Bundesliga form: LLDLDL
Paderborn will again be without the services of Luca Kilian due to a thigh problem, but the home side did not pick up any fresh injury concerns against Dusseldorf last weekend.
There are not expected to be many changes from the side that started last time out, although Marlon Ritter could be in contention for a spot in the final third of the field.
Head coach Schreuder is expected to consider changes from the side that started against Hertha, with former Borussia Dortmund attacker Jacob Bruun Larsen among those who could feature from the onset.
However, Ihlas Bebou should keep his spot for the visitors at the top end of the field.
Paderborn possible starting lineup:
Zingerle; Drager, Hunemeier, Schonlau, Collins; Proger, Vasiliadis, Gjasula, Antwi-Adjej, Jastrzembski; Srbeny
Hoffenheim possible starting lineup:
Baumann; Kaderabek, Akpoguma, Hubner, Posch; Grillitsch, Rudy; Zuber, Baumgartner, Larsen; Bebou
We say: Paderborn 0-1 Hoffenheim
Neither side will enter the match in a confident mood, but Hoffenheim's away form this season has actually been quite strong. Paderborn, on the other hand, have the second-worst home record in the division. We are not expecting many goals on Saturday afternoon but expect the visitors to pick up all three points.