The hosts are looking to avoid a sixth defeat in seven outings so far, while the away side set out to record a fourth consecutive victory.
Wuhan Three Towns maintained their perfect record on home turf this term courtesy of an emphatic 5-0 demolition of Hebei FC on Sunday.
Having amassed 16 of a possible 18 points, the Hubei-based outfit currently sit top of the Chinese Super League table and have laid down an early title marker.
Lying in store next is the challenge of an opposing side who suffered a heavy 6-0 defeat in the only previous meeting between the teams on June 7.
Ahead of a top-of-the-table clash against Shanghai Shenhua three days later, Thursday's visitors go in search of a morale-boosting triumph in this one.
Guangzhou failed in their quest to secure back to back wins for the first time since January as they were beaten 2-1 by Shanghai Shenhua on Sunday.
The South China Tigers remain 16th in the league standings but can take solace from the fact that they are only a point adrift of safety.
Having conceded the third-most goals (11) in the entire division, Thursday's hosts will need to be wary of being picked apart by the side with the most goals scored (21).
Guangzhou's Afrden Asqer missed his side's most recent involvement due to a one-game suspension, but the 18-year-old is now eligible to feature once again.
Off the back of ending a 10-game goalless streak for club and country last time out, Wei Shihao will be seeking to string together a good run of matches in front of goal.
Davidson and Nicolae Stanciu are ones to keep an eye on, as no player has been directly involved in more goals than the duo (seven each).
Both of the aforementioned players contributed to two goals apiece in the last edition of Wednesday's fixture, and Wuhan will be hopeful of a similar impact here.
Guangzhou possible starting lineup:
Liu; Hang, Yaki, Zhang, Tao; Ademilson, He, Stanciu, Xie; Davidson, Marcao
Wuhan Three Towns possible starting lineup:
Lui; Chen, Wu, Li, Wei; Fan, Yan, Huang, Yang; Wei, Ling
We say: Guangzhou 0-4 Wuhan Three Towns
Wuhan look unstoppable at the moment, and Guangzhou are the latest team to try to prevent the juggernaut from rolling on. We are backing the away side to cruise to a comfortable win, scoring plenty of goals en route.
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