This weekend's meeting will be the second between the sides this term with October's reverse fixture ending in a 1-1 draw.
Sparta Rotterdam played out a second consecutive home 1-1 stalemate on Sunday when they faced off against AZ Alkmaar on Saturday.
Consequently, De Rood-Witte Gladiatoren now sit bottom but one and three points away from safety in the Eredivisie table.
Lying in store next is a trip to an away ground where Sparta have won just one of their five matches stretching back to 2016.
However, that solitary win did come during their most recent trip back in May, when Saturday's visitors claimed a narrow 2-1 triumph.
Groningen's downward spiral continues following a 3-1 defeat against RKC Waalwijk at the Mandemakers Stadion on Sunday.
The Pride of the North remain eighth in the league standings but are now being hunted down by a number of teams just behind, with only two points separating them from Cambuur in 13th.
With just three games left to conclude the current campaign, Saturday's hosts simply have to turn a corner as soon as possible to avoid losing their Conference League playoff berth.
Adil Auassar shook off a minor knock to retain his place in the heart of the defence last time out, and the 35-year-old is expected to feature once again.
Groningen's Radinio Balker is a guaranteed absentee as he yet to feature this term due to a cruciate ligament injury.
Nineteen-year-old Tomas Suslov is also unavailable for this weekend's hosts due to a thigh problem.
Jan Hoekstra will not return to action until the next campaign having suffered a season-ending shoulder injury.
Groningen possible starting lineup:
Leeuwenburgh; Meijer, Van Hintum, Te Wierik, Dankerlui; Duarte, Kasanwirjo; Abraham, De Leeuw, El Hankouri; Larsen
Sparta Rotterdam possible starting lineup:
Okoye; Durmisi, Auassar, Vriends, Heylen, Abels; Masouras, Verschueren, Van Mullem, Jans; Thy
We say: Groningen 1-1 Sparta Rotterdam
Judging by previous meetings, we expect another tightly-contested affair in this one with the sides settling for a point apiece at the end of the 90 minutes.
Our analysis of all available data, including recent performances and player stats, suggests the most likely outcome of this match is a Groningen win with a probability of 54.1%. A draw has a probability of 25.2% and a win for Sparta Rotterdam has a probability of 20.65%.
The most likely scoreline is Groningen 1-0 Sparta Rotterdam with a probability of 13.65% and the second most likely scoreline is Groningen 1-1 Sparta Rotterdam with a probability of 11.86%.