Groningen in sixth are currently three points higher than Twente in seventh but as the visitors have a higher goal difference, they will overtake the home team if they emerge victorious.
Groningen have lost just one of their last eight league matches and were 3-2 winners over struggling Willem II on Thursday night.
It means that Danny Buijs's side remain just a point behind AZ Alkmaar, who occupy the final Europa League spot - a competition the Green-White Army have not qualified for since 2015.
Groningen's games at the Hitachi Stadion this season have tended to be low-scoring affairs as they have netted the joint-lowest amount of home goals in the division (eight) but conceded the third fewest (six).
However, there have been at least two goals in all of Twente's matches this season, including their 3-1 win over Groningen in the reverse fixture back in September.
The away form of Ron Jans's side is also promising as they have won their last four games on their travels, losing just once as the visiting side all season.
It continued the inconsistent form of the Tukkers, who have not lost consecutive league games so far this season but equally have not strung two wins together since the start of November.
They are aiming to qualify for the Europa League for the first time in seven years, having recovered from financial problems that relegated them to the second tier in 2018.
Groningen Eredivisie form: WWWLDW
Groningen form (all competitions): WLWLDW
FC Twente Eredivisie form: WLWLWL
Patrick Joosten came off with an injury 21 minutes into Groningen's clash with Willem II, with his replacement El Hankouri scoring twice, so the Moroccan should start on Sunday.
Arjen Robben is edging closer to a return, having not featured since late October because of a groin problem, but he is still a couple of weeks away from full fitness.
Twente have confirmed that the almost ever-present Vaclav Cerny will miss the rest of the season after picking up a serious knee injury just eight minutes into the game against Ajax.
Groningen possible starting lineup:
Padt; Dankerlui, Itakura, Van Hintum, Gudmundsson; Van Kaam, Matusiwa; Suslov, El Messaoudi, El Hankouri; Larsen
FC Twente possible starting lineup:
Drommel; Ebuehi, Pleguezuelo, Pierie, Smal; Bosch, Roemeratoe, Zerrouki; Ilic, Danilo, Menig
We say: Groningen 1-1 FC Twente
This should be an entertaining game between two well-matched sides, and it is a hard one to call. Groningen are solid at home, but Twente have impressive away form so we think that the points will be shared in this battle for Europe.