The reigning world champions struggled to cope with El Tri's pace and duly conceded on 35 minutes due to a swift counterattack finished off by Hirving Lozano.
Although Germany improved in the second half, they lacked end product and were unable to find an equaliser, condemning them to their first opening-day defeat at the tournament since 1982.
Despite the poor result, Low stressed that Die Mannschaft will not overhaul their tactics, though he admits that some flaws need to be ironed out.
"In the first half the impression was that we were not as dynamic as we usually are and in the second half I didn't have the impression we were losing strength," the 58-year-old told reporters.
"It was not a lack of stamina that meant we could not turn the match around. As a player in a World Cup you have to accept pressure.
"We will certainly not change our match plan. In the first half, to a large extent, the players were coming back trying to recover the ball instead of playing deep, if we are not more incisive we will lose the ball. We have to focus on our strong points."
Spain lost their first game at the 2010 World Cup but went on to win the tournament outright.