Bent returns to the first XI having come off the bench to score the only goal of the game in Fulham's 1-0 win over Stoke City earlier this month.
The striker is one of four changes made by Martin Jol, who also brings in Maarten Stekelenburg for his first appearance in more than two months. Kieran Richardson and Scott Parker also return to the starting lineup.
Palace, meanwhile, welcome Yannick Bolasie back from injury for his first start of the season, while Dwight Gayle also earns a starting place having come on to score against Liverpool in his last outing.
Crystal Palace: Speroni; Ward, Mariappa, Delaney, Moxey; O'Keefe, Jedinak, Campana, Puncheon, Bolasie; Gayle
Subs: Price, Gabbidon, Dikgacoi, Kebe, Thomas, Phillips, Chamakh
Fulham: Stekelenburg; Riether, Senderos, Hangeland, Richardson; Parker, Sidwell, Kasami, Ruiz; Berbatov, Bent
Subs: Stockdale, Amorebieta, Zverotic, Karagounis, Boateng, Duff, Rodallega