Another triumph in the capital this weekend could see Roberto Martinez's side go eight points clear of the drop zone.
Meanwhile, Fulham will extend their unbeaten run to four matches if they avoid defeat on home turf.
Wigan will hope to name Hugo Rodallega and Shaun Maloney in their squad following knee injuries, while the Cottagers may be without strike duo Pavel Pogrebnyak and Andrew Johnson.
Fulham: Schwarzer; Kelly, JA Riise, Hangeland, Hughes; Murphy, Duff, Diarra, Frei; Dempsey, Dembele
Wigan: Al Habsi; Alcaraz, Caldwell, Boyce, Figueroa; Diame, Moses, Gomez, McArthur, Beausejour; Di Santo
Sports Mole says: 1-1