Cottagers captain Danny Murphy misses out with a knee injury, while frontmen Clint Dempsey and Bobby Zamora haven't travelled.
Youngster Kerim Frei gets a spot on the bench, with Brede Hangeland taking the captain's armband for the night.
The Premier League side currently sit level with Twente at the top of the group on four points, while Wisla are yet to claim a point.
Fulham starting XI: Schwarzer; Kelly, Hughes, Hangeland (C), Briggs; Duff, Etuhu, Gecov, Dembele; Johnson, Sa
Wisla Krakow starting XI: Sergei Pareiko; Jaliens, Chavez, Diaz, Lamey; Gargula, Nunez, Kirm, Wilk; Biton; Illiev