France must end Ukraine's 12-match unbeaten run and overturn a 2-0 first-leg deficit on Tuesday if they are to reach next year's World Cup finals in Brazil.
Les Bleus conceded twice in the second half in Kiev on Friday night and then had Laurent Koscielny sent off in the final moments.
The Arsenal man's place at centre-back is likely to be taken by Mamadou Sakho of Liverpool.
Striker Karim Benzema started on the bench in Kiev but manager Laurent Blanc could start both him and Olivier Giroud in Paris as they need goals.
Ukraine will reach their second ever World Cup if they hold on to their lead from the first leg. In 2006, they reached the quarter-finals in Germany.
Manager Mykhaylo Fomenko will be without centre-back Oleksandr Kucher after he picked up two bookings in added time on Friday night, with Yaroslav Rakitskiy likely to start in his place.
Recent form
France: LWWWDD
Ukraine: WWWDWW
Possible starting lineups
France: Lloris; Sagna, Sakho, Abidal, Evra; Nasri, Pogba, Matuidi, Ribery; Giroud, Benzema
Ukraine: Pyatov; Fedetskyi, Khacheridi, Rakitskiy, Shevchuk; Tymoschuk, Rotan, Yarmolenko, Edmar, Konoplyanka; Zozulya
Sports Mole says: 2-1
No Data Analysis info
Netherlands
Senegal
Ecuador
Qatar
England
USA
Iran
Wales
Argentina
Poland
Mexico
Saudi Arabia
France
Australia
Tunisia
Denmark
Japan
Spain
Germany
Costa Rica
Morocco
Croatia
Belgium
Canada
Brazil
Switzerland
Cameroon
Serbia
Portugal
South Korea
Uruguay
Ghana
