Following N'Golo Kante's withdrawal from the squad after his hamstring injury, fellow Premier League star Anthony Martial got his studs caught in the turf against Kazakhstan and injured his knee in the process.
The Manchester United man tried to carry on before being forced to call it a day - which suggests that the injury is not too serious - but he will almost certainly make way for Olivier Giroud this week.
Kylian Mbappe was denied from the spot by 39-year-old Aleksandr Mokin at the weekend but will replace Thomas Lemar on the left either way, while Kingsley Coman is vying for a recall to the right-hand side despite Ousmane Dembele's opener last time out.
Didier Deschamps has urged caution over Paul Pogba's playing time, so the Man United man may not be deemed ready to start two games in quick succession, meaning a recall for Adrien Rabiot alongside Tanguy Ndombele.
Deschamps made a quartet of changes in defence against Kazakhstan but is sure to switch it up again here despite their clean sheet, starting with a return for Presnel Kimpembe after his unfortunate own goal against Ukraine.
Benjamin Pavard and Lucas Hernandez are in line to replace Leo Dubois and Lucas Digne in the full-back positions, while Raphael Varane should demote fellow La Liga defender Clement Lenglet back down the bench.
France possible starting lineup:
Lloris; Pavard, Varane, Kimpembe, Hernandez; Ndombele, Rabiot; Coman, Griezmann, Mbappe; Giroud