The home side overcame much-fancied Lazio in the previous round, while Benfica held off a late challenge from Newcastle United to book their spot in the final four of the competition.
Fenerbahce enter the match in good form having lost just one of their last five matches in all competitions, a run of form that has seen them move into second place in their domestic table, but they are seven points behind Galatasaray.
Benfica, meanwhile, are unbeaten in all competitions since the end of February. They currently sit four points clear of Porto in their domestic table having remarkably won 22 of their 26 league matches, remaining unbeaten in that period.
The Turkish outfit have no fresh injury concerns from their 2-0 defeat to Genclerbirligi at the weekend, with Dirk Kuyt and Pierre Webo expected to lead the line. Moussa Sow is also pushing for a start, but the forward may have to be content with a spot on the bench.
Benfica boss Jorge Jesus, meanwhile, could once more leave Oscar Cardozo on the bench in favour of Ola John. Rodrigo is also pushing for a start, but is expected to join Cardozo on the sidelines. Much-coveted defender Ezequiel Garay is fit, however, after overcoming a muscular strain.
Fenerbahce: Demirel; Korkmaz, Yobo, Ziegler, Gonul; Meireles, Baroni, Ucan, Erkin; Kuyt, Webo
Benfica: Artur; Almeida, Garay, Luisao, Melgarejo; Gaitan, Matic, Perez, Salvio; Lima, John
Sports Mole says: 1-1