Carlo Ancelotti will be without James Rodriguez, Fabian Delph, Abdoulaye Doucoure and Jean-Philippe Gbamin, who are all unavailable through injury, while there are also doubts over Gylfi Sigurdsson and Robin Olsen.
The Toffees will, however, welcome back defender Yerry Mina as well as club captain Seamus Coleman, whose Italian boss this week likened his leadership qualities to players such as Paolo Maldini and Sergio Ramos.
Coleman – who is 11 games away from becoming the sixth Everton player to reach 300 Premier League appearances – had been suffering from a minor setback after the Merseyside derby victory last month but is now in contention to feature against Burnley.
Ancelotti may decide to revert to a four-man defence after using Alex Iwobi as a right wing-back against Chelsea last weekend. As a result, midfielder Tom Davies could come into the starting lineup to replace the Nigerian with Coleman or Mason Holgate filling in at right-back.
Joshua King has made seven substitute appearances for the Toffees since joining from Bournemouth in January but is yet to start a match under Ancelotti and is again expected to begin this weekend's game from the bench.
Everton possible starting lineup: Pickford; Holgate, Godfrey, Keane, Digne; Davies, Allan, Gomes; Sigurdsson; Calvert-Lewin, Richarlison
Watch the Sports Mole Football Shorts prediction for this game below: