The Toffees revert to a four-man defence for tonight's first-leg tie, as they attempt to pick up a positive result to take with them to Croatia for next week's return match.
There is another start up top for Wayne Rooney, fresh on the back of scoring the only goal of the game against Stoke City in his first league game back at the club, while Davy Klaassen will provide support alongside Mirallas and Lookman in attack.
Hajduk, who drew 0-0 with Brondby in their last European away game, will this evening by led by Cameroonian forward Franck Ohandza.
Everton: Pickford; Martina, Keane, Williams, Baines; Schneiderlin, Gueye; Mirallas, Klaassen, Lookman; Rooney
Subs: Stekelenburg, Jagielka, Lennon, Besic, Calvert-Lewin, Davies, Holgate
Hajduk Split: Stipica, Memolla, Carbonieri, Nizic, Juranovic, Kozulj, Radosovic, Gentsoglou, Barry, Ohandza, Vlasic
Subs: Bosancic, Said, Letica, Basic, Sehic, Tudor, Erceg
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