The minnows, who have won just one international match in their history, have conceded 19 goals in their six Group E qualifying matches so far.
Five of those goals were shipped against the Three Lions at Wembley and ahead of the return meeting in Serravalle on Saturday, Simoncini conceded that San Marino have no chance of causing an upset.
"The result is the last thing I think about. When I go out onto the pitch, I concentrate on doing the best I possibly can. Basically, the best we can hope for is not getting hammered," he told 888sport.com
"Against Estonia, we drew 0-0 and I kept a clean sheet. For me, that was more than a victory. To keep a clean sheet at our level is a miracle. At this level, the margins are so much bigger. We try to do our best, but we're realistic. We value the performance at the end."
England have won all five of their previous meetings with San Marino, scoring 31 goals and conceding just one in the process.